The Jackson River (Covington, VA) is a regulated river receiving nutrient-enriched effluent from industrial sources and experiences high algal biomass downstream of the facilities.  Algal biomass and taxonomic studies, water quality analyses, and pulsed-flow experiments have been conducted over the past 9 years at upstream (P-limited reference) and downstream (N-limited) sites to develop a periphyton-oxygen-nutrient dynamics model and evaluate the effects of decreased nutrient discharges. Algal chl a is greatest immediately downstream of the facility, and decreasing >15 km downstream. Within-year variation shows the greatest chl a typically occurring in the fall.  Chl a was greatest in 2000 and 2002, with recent lower biomass possibly attributed to reduction in effluent nutrients; especially P.  Filamentous diatoms account for the greatest component of biomass downstream of the facility with Pleurosira laevis and Melosira varians contributing the largest proportion to overall biovolume. Biomass-flow relationships examined through rain events, artificial streamside channels, and an experimental pulse-flow dam release show significant negative relationships between biomass and flow. This long-term, multi-faceted study has shown relationships between algal biomass, flow, and nutrient inputs that will aid in model development, reducing nuisance algae, and developing effective management strategies for restoring and maintaining river health.