The accumulation of multiple stressors (e.g., urban development, forestry, mining, transportation, agriculture, climate change) has resulted in cumulative effects on the health of our waters. There is an urgent need to understand how aquatic systems are changing, to identify indicators for assessment, as well as to establish predictive relationships between landscape change and aquatic health. At the University of Saskatchewan, we are developing The Healthy River Ecosystem Assessment System (THREATS). THREATS is a geospatial tool for a GIS application-based software that integrates existing multi-jurisdictional and multi-sector databases on key aquatic indicators and compares these data with benchmarks to measure change. The utility of THREATS is to allow for relational comparisons between landscape change and aquatic health, to determine where changes have occurred, causative factors, and if changes exceed benchmarks.  The vision for THREATS is to provide integrated scientific information to better educate on the state of our waters and bring us closer to sustainable and scientifically defensible solutions to water-related issues.