Continuous enrichment of a detrital-based headwater stream for 2 years has resulted in strong bottom-up effects that have transcended multiple trophic levels (microbes, primary consumers, invertebrate predators, and vertebrate predators). We tested whether further nutrient enrichment would have similar positive effects on primary consumers and invertebrate predators in years 4 and 5 of enrichment. We found that total macroinvertebrate biomass and production continued to increase in the nutrient-enriched vs. reference stream in years 4 and 5, but that increases occurred in only some groups of primary consumers and not invertebrate predators. Specifically, shredder biomass and production continued to increase with nutrient enrichment, but invertebrate predator biomass and production declined to pretreatment levels. This positive shredder response can primarily be attributed to the increased dominance of a case-building caddisfly that is relatively predator-resistant (Pycnopsyche spp.). When such predator-resistant prey increase their relative community dominance over more predator-susceptible prey it can reduce predation rates and redirect energy flows away from higher trophic levels. Thus, the majority of the nutrient-enhanced energy flow through primary consumers in this system became relatively unavailable to predators over the 4-5 year time scale, resulting in a trophic redirection.